The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction of drug lost during the process of absorption which is generally related to the liver and gut wall.
First-pass elimination takes place when a drug is metabolised between its site of administration and the site of sampling for measurement of drug concentration. Clinically, first-pass metabolism is important when the fraction of the dose administered that escapes metabolism is small and variable ...
first-pass elimination: First-pass effect, first-pass metabolism, presystemic elimination Pharmacology The rate at which circulating drugs are metabolized as they traverse the liver, before they reach the systemic circulation
First Pass Effect. A first-pass effect is defined as the rapid uptake and metabolism of an agent into inactive compounds by the liver, immediately after enteric absorption and before it reaches the systemic circulation.
First-pass metabolism refers to the 'first passage' of drug through the liver, after absorption from the GI tract, as explained above. If the major proportion of an active drug is converted to ...
Because the liver is the primary organ of metabolism, the consequence of first-pass metabolism is the break down of significant amounts of a drug before it can reach the systemic circulation, so those drugs never reach the site of action!
First Pass Metabolism: Definition and core concepts. Learn pharmacology with my other videos below: (1) Pharmacokinetics & ADME: http://youtu.be/CMRZqdrkCZw ...
The First Pass Effect. When you take a medication by mouth, it doesn't just magically get into your body and start doing its thing. It actually has to go through a whole host of organs and a big ...
First Pass Yield is an important manufacturing metric for measuring quality and production performance and there are many benefits to including first pass yield in the manufacturing executive's dashboard.First pass yield is a good measure of the effectiveness of a process and the elimination of waste from that process.
first-pass effect: the intestinal and hepatic degradation or alteration of a drug or substance taken by mouth, after absorption, removing some of the active substance from the blood before it enters the general circulation. Synonym(s): first-pass effect