Web Results

www.ncbi.nlm.nih.gov/pubmed/6362950

First-pass elimination takes place when a drug is metabolised between its site of administration and the site of sampling for measurement of drug concentration. Clinically, first-pass metabolism is important when the fraction of the dose administered that escapes metabolism is small and variable ...

en.wikipedia.org/wiki/First_pass_effect

The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction of drug lost during the process of absorption which is generally related to the liver and gut wall.

medical-dictionary.thefreedictionary.com/first-pass+elimination

first-pass elimination First-pass effect, first-pass metabolism, presystemic elimination Pharmacology The rate at which circulating drugs are metabolized as they traverse the liver, before they reach the systemic circulation

www.sciencedirect.com/.../first-pass-effect

A first-pass effect is defined as a low systemic availability of the drug as a result of significant metabolism. Although a first-pass effect can occur in a variety of tissues, including the intestines Doherty and Pang (1997) and uterus De Ziegler et al (1997), it is most often observed with the liver.

www.researchgate.net/post/Can_someone_provide_a_simple_explanation_for_the_1st...

Can someone provide a simple explanation for the 1st pass effect? ... First-pass metabolism refers to the 'first passage' of drug through the liver, after absorption from the GI tract, as ...

www.pharmacology2000.com/General/Pharmacokinetics/kinobj1F.htm

Overall process that contributes to bioavailability reduction is the first-pass lost or elimination; Magnitude of first pass hepatic effect: Extraction ratio (ER) ER = CL liver / Q ; where Q is hepatic blood flow (usually about 90 L per hour

medical-dictionary.thefreedictionary.com/first-pass+effect

first-pass metabolism the intestinal and hepatic degradation or alteration of a drug or substance taken by mouth, after absorption, removing some of the active substance from the blood before it enters the general circulation. Synonym(s): first-pass effect first-pass me·tab·o·lism , first-pass effect (fĭrst-pas mĕ-tab'ŏ-lizm, e-fekt') The ...

quizlet.com/70075057/first-pass-effect-flash-cards

Because the liver is the primary organ of metabolism, the consequence of first-pass metabolism is the break down of significant amounts of a drug before it can reach the systemic circulation, so those drugs never reach the site of action!

www.youtube.com/watch?v=5AB8WkCbz4k

First Pass Metabolism: Definition and core concepts. Learn pharmacology with my other videos below: (1) Pharmacokinetics & ADME: http://youtu.be/CMRZqdrkCZw ...

study.com/academy/lesson/the-first-pass-effect-in-pharmacology.html

The First Pass Effect. When you take a medication by mouth, it doesn't just magically get into your body and start doing its thing. It actually has to go through a whole host of organs and a big ...