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study.com/academy/lesson/the-first-pass-effect-in-pharmacology.html

The First Pass Effect. When you take a medication by mouth, it doesn't just magically get into your body and start doing its thing. It actually has to go through a whole host of organs and a big ...

en.wikipedia.org/wiki/First_pass_effect

The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug, specifically when administered orally, is greatly reduced before it reaches the systemic circulation. It is the fraction of drug lost during the process of absorption which is generally related to the liver and gut wall.

www.sciencedirect.com/.../first-pass-effect

PHARMACOLOGY. First-Pass Effect. Drugs that are administered orally (as opposed to intravenously, intramuscularly, sublingually, or transdermally) must first pass from the intestine to the liver before reaching the general circulation. Thus, for many drugs, much of the dose is reduced by xenobiotic metabolism before reaching the tissues.

www.wisdomjobs.com/.../pharmacology-tutorial-128/the-first-pass-effect-13903.html

This is referred to as the first pass effect. Not all drugs are metabolized in the liver. Some drugs bypass the first pass effect by sublingual administration (under the tongue) or buccal administration (between the gums and the cheek) where they are absorbed directly into the bloodstream from the mouth.

study.com/academy/practice/quiz-worksheet-1st-pass-effect-in-pharmacology.html

What is the first pass effect in pharmacology? Gauge your knowledge of this effect and roles of the intestines by using the quiz and worksheet. Quiz & Worksheet Goals.

onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2036.1987.tb00634.x

The bioavailability of orally administered drugs may be reduced due to presystemic elimination. The first‐pass effect can occur in the gastrointestinal tract, the liver and lung. Although the liver is the main drug metabolizing organ in the body, the gut wall can play an important role in the first‐pass metabolism of certain drugs.

pubmed.ncbi.nlm.nih.gov/6362950

First-pass elimination takes place when a drug is metabolised between its site of administration and the site of sampling for measurement of drug concentration. Clinically, first-pass metabolism is important when the fraction of the dose administered that escapes metabolism is small and variable. Th …

socratic.org/questions/what-is-meant-by-the-first-pass-effect-of-drugs

first-pass effect is a process in which a drug administered by mouth is absorbed from the gastrointestinal tract and transported via the portal vein to the liver, where it is metabolized. As a result, in cases of some drugs, only a small proportion of the active drug reaches the systemic circulation and its intended target tissue.

www.amboss.com/us/knowledge/Fundamentals_of_pharmacology

First pass effect: Orally administered drugs are absorbed from the GI tract and reach the liver via the portal circulation.; In the liver they undergo first pass metabolism before they enter systemic circulation, which decreases the bioavailability of the drug.