Abstract. To investigate the effect of age and gender on ethanol metabolism, first-pass metabolism (FPM) and gastric alcoholdehydrogenase (ADH) activity were compared in 32 elderly and 30 young adult nonalcoholic subjects.
stomach, all first-pass metabolism of alcohol is said to occur in the gastric mucosa because hepatic alcohol dehydrogenase is saturated at low peripheral blood alcohol concentrations. We evaluated the ability of the liver to carry out first-pass metabolism in the rat by constructing a model of the hepatic ...
In nonalcoholic subjects, the first-pass metabolism and gastric alcohol dehydrogenase activity of the women were 23 and 59 percent, respectively, of those in the men, and there was a significant ...
Other possible factors contributing to observed lower mean 11-OH-THC [C.sub.max] and [AUC.sub.0 [right arrow] 10.5 h] after high-dose Sativex were facilitated THC absorption through the oral mucosa and reduced first-pass metabolism.In the present study, THC bioavailability was enhanced when THC was administered by oromucosal spray, compared with oral administration, although differences did ...
Introduction: In the 1980s–1990s numerous studies were performed on H 2-receptor antagonist inhibition of ethanol first-pass metabolism.Blood alcohol concentrations warranting possible driving under the influence citations in the United States have subsequently dropped from ≥100 mg/dL to 50 mg/dL (Utah in 2019) (30 mg/dL or zero tolerance in some parts of the world).
The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug, specifically when administered orally, is greatly reduced before it reaches the systemic circulation. It is the fraction of drug lost during the process of absorption which is generally related to the liver and gut wall.
The interaction of ethanol and lipid metabolism is relevant to the effect of alcohol consumption on body weight and body composition, to the pathogenesis of alcoholic fatty liver and hyperlipidemia, and to atherosclerosis. ... High blood alcohol levels in women: role of decreased gastric alcohol dehydrogenase activity and first pass metabolism ...
Alcohol metabolism is the process through which your body breaks down and rids itself of alcohol. When you swallow alcohol, it soaks into the tissues of your stomach and upper intestine. From there, the alcohol floods your bloodstream. In healthy people, blood circulates throughout the body in just 90 seconds.
After first pass metabolism, the remaining ethanol and its metabolites are distributed in different tissue, and the excess alcohol is excreted in the breath, urine, and sweat . The distribution of ethanol throughout the body is driven in direct proportion to water content of each tissue, especially at the ethanol steady-state.
There also are reports that women possess a lower capacity than men to oxidize ethanol in the gut, a process called first-pass metabolism (Frezza et al. 1990). This deficit in women allows greater quantities of ethanol into the portal circulation, thereby exposing their livers to higher ethanol concentrations.