Endometrial thickness is a commonly measured parameter on routine gynecological ultrasound and MRI. The appearance, as well as the thickness of the endometrium, will depend on whether the patient is of reproductive age or postmenopausal and, if of reproductive age, at what point in the menstrual cycle they are examined.
The measurement of endometrial thickness by TVUS is now almost standard in the evaluation of postmenopausal bleeding. However, screening asymptomatic women for endometrial cancer with TVUS is not recommended.
In women without vaginal bleeding, the threshold separating normal from abnormally thickened endometrium is not known. The aim of this study was to determine an endometrial thickness threshold that should prompt biopsy in a postmenopausal woman without vaginal bleeding.
That means if you have post menopausal bleeding (which has a 10% chance of being a cancer among all comers), an endometrial thickness below 3mm on transvaginal sonogram reduces your chance of cancer from 10% to 0.6%, while the old 5 mm cutoff would have reduced you odds to 1%.
The mean endometrial thickness in postmenopausal women is much thinner than in pre-menopausal women. Thickening of the endometrium may indicate the presence of pathology. In general, the thicker the endometrium, the higher the likelihood of important pathology, ie endometrial cancer being present.
Transvaginal ultrasonography usually is sufficient for an initial evaluation of postmenopausal bleeding if the ultrasound images reveal a thin endometrial echo (less than or equal to 4 mm), given that an endometrial thickness of 4 mm or less has a greater than 99% negative predictive value for endometrial cancer.
Endometrial sampling in a postmenopausal woman without bleeding should not be routinely performed. (II-1E) Indications for tissue sampling of the endometrium in bleeding postmenopausal women with an endometrial thickness of greater than 4 to 5 mm should not be extrapolated to asymptomatic women. (II-2E)
If a woman who has already gone through menopause suddenly has bleeding, and an ultrasound test shows that her uterine lining is thicker than 4 to 5 mm, she may need an endometrial biopsy to make ...
Endometrial hyperplasia occurs when the endometrium, the lining of the uterus, becomes too thick. It is not cancer, but in some cases, it can lead to cancer of the uterus. It is not cancer, but in some cases, it can lead to cancer of the uterus.
Endometrial cancer is the most common invasive gynecologic cancer in U.S. women, with an estimated 61,880 new cases expected to occur in 2019 and an estimated 12,160 women expected to die of the disease. Endometrial cancer is primarily a disease of postmenopausal women, with a mean age at diagnosis of 60 years.