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Immunoglobulin E (IgE) is an antibody that is produced by the body’s immune system and is associated with allergic responses, including asthma, and to a lesser degree with immunity to parasites. The total IgE test may be used to screen for and detect allergic diseases.


An elevated level of total IgE suggests that the person is allergic to one or more substances. The total IgE level of a person who is allergic to a single substance will be much less than that of a person who is allergic to multiple allergens. So, a total IgE blood test is conducted in order to detect allergic disorders.


Hyper IgE Syndrome (HIES) is a rare primary immunodeficiency disease characterized by eczema, recurrent staphylococcal skin abscesses, recurrent lung infections, eosinophilia (a high number of eosinophils in the blood) and high serum levels of IgE. Most cases of HIES are sporadic, but some familial cases of HIES have been reported, with either an autosomal dominant (AD) or autosomal recessive ...


People who have elevated IgE levels can have environmental or food allergies. If you get a blood test and it shows that you have an elevated IgE that could mean you are an allergic patient. A total elevated IgE just tells you that you have a high chance of allergies, but it does not tell you specifically what you are allergic to.


Atopic disease is likely if the total IgE level is 375 IU/mL or greater. If the total IgE level is very low, atopic disease can usually be excluded. Conversely, it is less common to find an elevated IgE level in a patient with immediate hypersensitivity to a single aeroallergen.


What Is a High IgE Blood Level? For adults, elevated levels of immunoglobulin E or IgE are above 423 international units per milliliter of blood, according to WebMD. Normal values of IgE rest between 3 and 423 international units per milliliter of blood.


Hyper-IgE syndrome: The prototypic example of a primary immunodeficiency disorder with an elevated total IgE level is the rare Hyper-IgE syndrome, also known as Job syndrome. Patients characteristically have recurrent abscesses, pneumonias or bronchiectasis.


An elevated concentration of total immunoglobulin E (IgE) is not diagnostic for allergic disease, and must be interpreted in the clinical context of the patient, including age, gender, travel history, potential allergen exposure, and family history. A normal concentration of total IgE does not eliminate the possibility of allergic disease.


Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isotype") that has only been found in mammals. IgE is synthesised by plasma cells. Monomers of IgE consist of two heavy chains (ε chain) and two light chains, with the ε chain containing 4 Ig-like constant domains (Cε1-Cε4).


Your doctor will likely measure your IgE levels if you have a blood test to check for allergies. ... If your immunoglobulin level is high, it might be caused by: ... What Is a Total Serum Protein ...