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Many appear to be primarily metabolized by the liver, and both parent drugs and metabolites are excreted in the urine. Patients with renal and/or liver disease may be at greater risk for adverse effects from antihistamines due to drug and metabolite accumulation. Therapy with antihistamines should be administered cautiously in such patients.


Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Fung on benadryl and liver damage: There is a "caution" warning for this medication with any liver impairment. Discuss this with your liver specialist.


Diphenhydramine has not been linked to instances of clinically apparent acute liver injury. Background . Diphenhydramine (dye" fen hye' dra meen) is a first generation antihistamine that is used widely in the therapy of the symptoms of allergic rhinitis and the common cold, including sneezing, cough, runny note, watery eyes and itching.


Find patient medical information for Benadryl Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.


Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the Unites States and accounts for 10% of acute hepatitis cases. We report the only known case of diphenhydramine-induced acute liver injury in the absence of concomitant medications. A 28-year-old man with history of 13/14-chromosomal translocation presented with fevers, vomiting, and jaundice.


Yes, Benadryl (diphenhydramine) is extensively metabolized by the liver. With abuse or overdose of diphenhydramine, liver damage can (and likely will) occur. There are also other side effects such ...


This study is created by eHealthMe based on reports of 53,315 people who have side effects when taking Benadryl from FDA, and is updated regularly. Do you have Liver function test abnormal while taking Benadryl? Personalized this study to your gender and age, or subscribe to monitor Liver function test abnormal in Benadryl.


Benadryl (diphenhydramine) is an antihistamine used to treat allergies, hives, insomnia, motion sickness, and mild cases of Parkinsonism.Benadryl is available in generic form and over-the-counter ().Common side effects of Benadryl include: drowsiness, fatigue, tiredness, sleepiness, dizziness, disturbed coordination,


Long-Term Side Effects of Benadryl. Benadryl (diphenhydramine hydrochloride) is a brand name antihistamine drug with anticholinergic (drying) and sedative side effects manufactured by McNeil Healthcare, a division of Johnson & Johnson. It is primarily prescribed to provide temporary relief of seasonal and perennial allergy symptoms including rashes, hives, runny nose, sneezing, itching and ...


Benadryl is excessively metabolized by the liver. (Overdrive) It can also lead to heart failure. Stressing your liver will result in negative results. Watch for fever and pain on your right side under the rib cage. Immediately change your behavior...