Web Results

www.rxlist.com/drug-interaction-checker.htm

Most drug metabolism takes place in the liver, but other organs also may play a role (for example, the kidneys, intestine, etc.). The cytochrome P450 enzymes are a group of enzymes in the liver that are responsible for the metabolism of most drugs. They are, therefore, often involved in drug interactions. ...

www.aafp.org/afp/2007/0801/p391.html

The target drug may need to be substituted or the dose adjusted to account for a potential decrease or increase in metabolism. Information regarding a drug's CYP450 metabolism and its potential ...

www.uspharmacist.com/article/fooddrug-interactions

Not only do foods affect the metabolism of drugs, but also in some cases, drugs interact with and alter the metabolism of food additives, such as caffeine. While it is appropriate to consider caffeine as a drug itself, rather than a food additive, some patients may disregard the fact that a high content of caffeine is found in coffee, tea, soft ...

www.researchgate.net/publication/311498332_Psychotropic_Medications...

Although the liver plays the major role in drug metabolism [e.g. by oxidative cytochrome P450 (CYP)-dependent phase I and conjugation or phase II reactions], drug metabolising enzymes are also ...

link.springer.com/chapter/10.1007/978-1-4899-6844-9_1

Drug metabolism is normally divided into two phases, phase I (or functionalisation reactions) and phase II (or conjugative reactions). The chemical reactions normally associated with phase I and phase II drug metabolism are given in Table 1.1.

www.ajmc.com/view/a370_11sep_overholser_s276tos287

Drug interactions of clinical significance with opioid analgesics. Drug Saf. 1993;8(1):30-48. Smith HS. Opioid metabolism. Mayo Clin Proc. 2009;84(7):613- 624. Daly AK. Significance of the minor ...

www.sciencedirect.com/.../drug-interaction

Mechanistic static models incorporate detailed drug disposition and drug interaction mechanisms for both drugs in an interaction [137].For example, parameters such as bioavailability and fractional metabolism data (e.g., “f m ” by specific CYP enzymes) for substrate drugs and K i for inhibitors are incorporated into these models [20].PBPK models are even more complex than static models in ...

pharmaxchange.info/2011/04/pharmacokinetics-basics-absorption-distribution...

Phase I Metabolism. These enzymes modify the drug chemically by processes such as oxidation, reduction and hydrolysis or by the removal and addition of an active group. Phase II Metabolism. These include the conjugation of a drug or a phase I metabolite with a polar group to render it possible for excretion. e.g. sulphates and glucuronide.

www.pharmacytimes.com/publications/issue/2014/december2014/drug-interactions...

Drug Metab Rev. 2014;46:86-95. 6. Jiang R, Yamaori S, Takeda S, et al. Identification of cytochrome P4540 enzymes responsible for metabolism of cannabidiol by human liver microsomes.

www.reddit.com/r/Drugs/comments/4mmhet/fast_metabolism_affecting_drug_duration

Being skinny and metabolizing drugs rapidly are not at all related. How your body deals with body fat and energy storage and drugs is completely different. Drug metabolism is generally affected by specific enzymes and is really unlikely to affect all drugs. The ritalin high doesn't last that long so that's not surprising.