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The amount of BNP in your blood is measured as pg/mL or 'picograms per milliliter'. Measuring The Values of Brain Natriuretic Peptide or BNP Test. A reading of 0-99 pg/mL is considered normal. Any reading from 100 - 900 pg/mL is considered abnormal and can indicate heart failure at varying levels of severity.
The normal range for brain natriuretic peptide levels is zero to 99 picograms per milliliter, notes WebMD. This can also be converted to zero to 99 nanograms per liter. Brain natriuretic peptide is made in the heart and appears in the blood, states WebMD. When the heart works harder, it releases more brain natriuretic peptide.
B-Type Natriuretic Peptide (BNP) blood test BNP is a substance secreted from the ventricles or lower chambers of the heart in response to changes in pressure that occur when heart failure develops and worsens. The level of BNP in the blood increases when heart failure symptoms worsen, and decreases when the heart failure condition is stable.
Many used to treat heart failure can alter BNP levels. Diuretics such as spironolactone and AT-1/AT-2 receptor blockers, can all reduce natriuretic peptide concentrations. Therefore, many patients with chronic stable heart failure will have BNP levels in the normal diagnostic range (i.e., BNP level less than 100 pg per mL [100 ng per L]).
The most important use of natriuretic peptides is in helping to establish the diagnosis of heart failure (HF) in a patient in the urgent care setting in whom the diagnosis is uncertain. The reference values of brain-type natriuretic peptide (BNP) and N-terminal (NT) proBNP are different to exclude or confirm a diagnosis of heart failure.
NT-proB-type Natriuretic Peptide (BNP) blood test. B-type natriuretic peptide (BNP) is a hormone produced by your heart. N-terminal (NT)-pro hormone BNP (NT-proBNP) is a non-active prohormone that is released from the same molecule that produces BNP. Both BNP and NT-proBNP are released in response to changes in pressure inside the heart.
In the previous issue of Critical Care, Meaudre and colleagues measured bedside rapid assay B-type natriuretic peptide (BNP) levels daily, and performed bedside echocardiography in patients admitted to hospital for subarachnoid hemorrhage (SAH) .They found that BNP levels rose in 25/31 (81%) patients, peaking at day 2 (at a mean of 126 ng/ml) and tapering off by day 7.
Brain natriuretic peptide (BNP) is important in the diagnosis and management of heart failure (HF). Sometimes, very high BNP levels encountered in clinical settings seem to be out of proportion to the severity of HF. The authors retrospectively identified 113 patients with 129 admissions with a BNP value >3000 pg/mL regardless of diagnosis.
And in patients who had BNP levels measured when they were hospitalized for acute coronary events, high BNP levels predicted a high risk of death during the next two years. BNP testing will never replace treadmill tests, heart scans, or coronary angiography for patients with suspected or proven CAD.