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www.reddit.com/r/Nootropics/comments/3cb95w/clonidine_seems_like_an_excellent...

That said, I don't know how clonidine effects cortisol in healthy (non depressed) humans. But the biggest downside of the alpha2 adrenergic agonists (clonidine, guanfacine) for cognitive enhancement is the depression that they seem to bring on in many people.

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Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels to relax and your heart to beat more slowly and easily. The Catapres brand of clonidine is used to treat hypertension (high blood pressure).

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Clonidine is a drug that is used primarily to treat high blood pressure by acting as an α2 adrenergic agonist. It also has been approved to treat ADHD (attention-deficit hyperactivity disorder), anxiety disorders, and panic attacks. In some cases it is even used to help manage chronic pain and is a commonly used drug to help ease opiate withdrawal symptoms.

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www.drugs.com/answers/clonidine-xanax-vicodin-720588.html

No, it is not the same as Xanax or Vicodin. Xanax is a benzodiazepine and Vicodin is a combination pain reliever with an opioid. Clonidine is actually closely related to Tizanidine which is a muscle relaxer.. Both clonidine and tizanidine are centrally acting alpha agonists. Tizanidine doesnt reduce blood pressure to the degree clonidine does ...

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Recently reports have been emerging in medical journals of opiate addicts abusing clonidine to get a opiate like high. I also found a government website that lists clonidine as a emerging drug of abuse and found reports that clonidine is being sold on the streets of new york.