How to Calculate the Calcium-Phosphorus Product. Calcium and phosphorus are two critical elements in the function of a variety of different physiological processes within the body including muscle contraction, nerve transmission and bone resorption. Although they function in many of the same processes, normal blood concentration levels of the two minerals is crucial for optimal health.
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calcium-phosphorus product should be maintained 2at < 255 mg2/dL (4.4 mmol /L2). (evidence). This is best achieved by controlling serum levels of phosphorus within the target range. (opinion) UK Renal Association: No recommendation. Canadian Society of Nephrology: No recommendation.
The calcium-phosphate product and use of oral calcium-based phosphate binders also significantly decreased after conversion… Valvular heart disease in patients with end-stage renal disease …management of secondary hyperparathyroidism, hyperphosphatemia, hypercalcemia, increased calcium/phosphate product , and hypertension.
Recent interests have mainly focused on the roles of serum calcium and phosphorus and their product (Ca-P product) in the development of valvular heart disease. The present study assessed the relationship between the Ca-P product and the severity of valvular heart disease in end-stage renal disease ...
Calcium-phosphorus product. Your calcium-phosphorus product (Ca x P) is your blood calcium level times your blood phosphorus level.This result should be part of your monthly blood test results. The NKF KDOQI guidelines for people on dialysis say that your product should be less than 55. You can reach this with a lower calcium level, lower phosphorus, or both.
HISTORY OF THE CALCIUM-PHOSPHORUS PRODUCT. In 1917, Binger 1 showed that infusion of phosphate produced tetany in dogs, demonstrating for the first time the inverse relationship between circulating calcium and phosphate concentrations. The assumption that this was due to the precipitation of calcium phosphate was incorporated into early studies of bone formation.
The predictive value of the Ca × P product was similar, while increased serum Ca levels were a weaker, though still significant risk predictor. Hyperphosphataemia and an increased serum Ca × P product were also found to be associated with the presence or magnitude of vascular and valvular calcifications in some, but not in all studies.
GUIDELINE 6. SERUM CALCIUM AND CALCIUM-PHOSPHORUS PRODUCT. In CKD Patients (Stages 3 and 4): 6.1 The serum levels of corrected total calcium should be maintained within the "normal" range for the laboratory used.
Calcium is usually sequestered within endoplasmic reticulum (which acts as a reservoir to release stores) and mitochondria. It is also bound to cellular proteins, e.g. troponin C, calmodulin. Leakage of calcium from mitochondria is a marker of mitochondrial injury and low intracellular stores of calcium result in cytotoxicity and cell death.
Calculated serum calcium-phosphorus product The interaction of serum calcium with serum phosphorus is important. Those animals with a calculated serum calcium-phosphorus product greater than 70 when total serum calcium concentration is multiplied with serum phosphorus concentration are most likely to have severe tissue changes associated with ...