Blue sclera: a bluish coloration of the whites of the eyes. The blue color is caused by thinness and transparency of the collagen fibers of the sclera, allowing the veins in the underlying tissue to show through. Blue sclerae are characteristic of a number of conditions, particularly connective tissue disorders.
Introduction: This information shows the various causes of Blue sclerae, and how common these diseases or conditions are in the general population.This is not a direct indication as to how commonly these diseases are the actual cause of Blue sclerae, but gives a relative idea as to how frequent these diseases are seen overall.. 1 disease that is "rare".
Blue (blue) sclera can be a symptom of a number of systemic diseases. "Blue sclera" is most often a sign of Lobstein-van der Heve's syndrome, which belongs to the group of constitutional defects of connective tissue, due to numerous genetic injuries. The type of inheritance is autosomal dominant, with high (about 70%) pervetrence.
Blue sclerae: Introduction. Blue sclerae: Blue colouring of the sclerae in the eye. See detailed information below for a list of 47 causes of Blue sclerae, Symptom Checker, including diseases and drug side effect causes. » Review Causes of Blue sclerae: Causes | Symptom Checker » Causes of Blue sclerae: The following medical conditions are some of the possible causes of Blue sclerae.
This section discusses 47 medical conditions causing Blue sclerae. A simple discussion of these causes with additional information is below. Causes of Blue sclerae: The following medical conditions are some of the possible causes of Blue sclerae. There are likely to be other possible causes, so ask your doctor about your symptoms.
Blue sclerae, especially at infancy, is the most visible ocular sign in osteogenesis imperfecta but it is not always present. It is also often present in normal infants. In some patients, it is present early but disappears later in life. Some patients have significantly lower ocular rigidity, corneal diameters, and decreased globe length.
Osteogenesis imperfecta (OI), also known as brittle bone disease, is a group of genetic disorders that mainly affect the bones. It results in bones that break easily. The severity may be mild to severe. Other symptoms may include a blue tinge to the whites of the eye, short height, loose joints, hearing loss, breathing problems and problems with the teeth.
A blue appearance of the sclera is really due to thinning of the sclera allowing the bluish color of the choroid to show through. In older adults there often develops a localized blue spot on the visible conjunctiva called a 'scleral plaque'.
Blue sclera (whites of the eyes) Easy bruising; Mild delay in motor skills; Type II. Severe; usually results in stillborn birth or death in the first months of life; Severe bone deformity; Type III. Most severe, nonlethal form; Hundreds of fractures starting very early in life; Severe bone deformities and physical disability that worsen over time
Blue pigmentation of the sclera and ears are often the earliest changes, with the arthritic complications usually presenting after the age of 40. Primary adrenal insufficiency (Addison’s disease) is usually caused by autoimmune destruction of the adrenal glands leading to cutaneous hyperpigmentation and salt-wasting.