The lethal dose of diphenhydramine, the generic name of Benadryl, varies significantly from person to person because of differences in weight and metabolism. There have been cases of people experiencing overdose symptoms with 500 milligrams of diphenhydramine and some cases where overdose is as high as 2,800 milligrams.
Research has shown that it is possible to survive a Benadryl overdose, depending on one’s weight, height and gender, although there may be permanent consequences to one’s health. Benadryl has a high therapeutic index, meaning that the amount requi...
Benadryl is not a sedative, and any attempts to sedate a person with Benadryl will only result in forcing someone to take a lethal dose of the drug.
Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Kluwe on diphenhydramine lethal dose: 50 mg half an hour prior to bed. Some people respond fine to 25 mg.
The normal dosage of Benadryl in dogs is 1mg/lb body weight whereas the normal dosage of Benadryl for children is 0.5mg/lb (every six hours or so); this means that the normal dose for a 20lb child would be the normal dose for a 10lb dog, different animals require different dosage per pound as each animal (including humans) work slightly ...
The American Journal of Nursing ("a lethal dose of diphenhydramine is about 2.8 grams"). Pharmacy Practice News (May 2014) suggests that a dose of 850 mg to 1000mg (1 gram) is sufficient to cause cardiotoxicity leading to death. Credentials and reliability .
Intake of diphenhydramine of doses exceeding the therapeutic dose will result in antihistamine toxicity. Lethal levels of diphenhydramine in the blood include higher than 19 mg/L, 7 mg/L and 1.5 mg/L in adults, children and infants respectively. Overdose of the drug can yield diphenhydramine hydrochloride overdose symptoms.
Diphenhydramine causes drowsiness, lethargy, and sleep even at doses recommended for anti-histamine use. The dosages below are reflective of recreational use where users take doses 4-20 times the recommended dose, stay awake, and try to enjoy the "drunken", delusional state.
One important success factor is the dosage - how much of any particular drug needs to be taken for it to be lethal. Minimum lethal doses (MLDs) were historically calculated based on animal testing, with the results extrapolated for humans. After all, you can't test how much of a certain drug is required to make a human die.
Detailed Diphenhydramine dosage information for adults and children. Includes dosages for Insomnia, Allergic Rhinitis, Allergic Reaction and more; plus renal, liver and dialysis adjustments.