Osteosclerosis is characterized by the abnormal hardening of bones. As of 2011, the genetic defect or mutation that causes this condition is not yet known, according to LivingNaturally.com. However, prostate cancer, hema... More »

According to the Free Dictionary, senile nuclear sclerosis describes a type of cataract that is characterized by a gradual hardening of the nucleus of the lens. This type of cataract is usually brown or black in color an... More »

Also referred to as peripheral artery disease, arterial disease in the legs is caused by a condition called arteriosclerosis, hardening of the arteries. This condition occurs when plaque accumulated on the walls of the a... More »

A hardening of the lens of the eye associated with aging, other medical conditions and certain drugs causes presbyopia, according to Mayo Clinic. People with the condition cannot focus on close-up images, as the lens is ... More »

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Scleroderma is a skin disease that involves hardening and stiffening of the skin and connective tissues, according to Mayo Clinic. It occurs when the body's immune system produces too much collagen, resulting in thicker,... More »

Hyperextension of the toes in either direction causes a large part of the foot to dorsiflex, or bend backwards, which results in a hardening of the muscles of the foot and a painful muscle cramp, according to WebMD. Extr... More »

The symptoms of CREST syndrome include red spots or lines on the skin, hardening of the skin, difficulty swallowing, bumps under the skin and a condition known as Raynaud's phenomenon, according to Mayo Clinic. While som... More »

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