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www.reference.com/science/irregular-z-lines-esophagus-a61...

Irregular Z-lines in the esophagus are displacements of the stratified squamous epithelium and the columnar epithelium in the tube that connects the stomach to the throat. The National Institutes of Health state that irregular Z-lines typically lead to a diagnosis of Barrett's esophagus.

www.healthtap.com/topics/irregular-z-line-esophagus

Helpful, trusted answers from doctors: Dr. Legha on irregular z line esophagus: Before I can guide you further, you need to tell me about your symptoms that lead you to have endoscopy done? The findings on endoscopy show significant abnormalities which, I am sure, your doctor must have shared with you. Did he recommend you to take treatment for Esophagitis and the Gastritis which your medical ...

www.answers.com/Q/What_is_irregular_z_line_in_esophagus

Irregular Z line is the connection where the oesaphagus meets the stomach. when the endoscopist means Irregular Z line- They take a sample tissue and send it for biposy.

www.medscape.org/viewarticle/705101_4

In some instances, the endoscopist may have observed an 'irregular, 'jagged or 'wavy Z-line that may or may not have been noted to be slightly proximally displaced from the anatomic gastroesophageal junction, and which indicated to the endoscopist the presence of a short (or more appropriately, ultrashort) segment of Barrett esophagus.

www.medscape.com/viewarticle/877833

Low Risk of High-Grade Dysplasia or Esophageal Adenocarcinoma Among Patients With Barrett's Esophagus Less Than 1 cm (Irregular Z Line) Within 5 Years of Index Endoscopy

www.mdjunction.com/forums/barrett-esophagus-discussions/...

Firstly there's no need to worry. An irregular z-line is actually quite common. It usually means there are some cardial cells (from the stomach) a little higher into what would normally have been thought of as the esophagus.

www.healingwell.com/community/default.aspx?f=45&m=2039967

Normally, the Z-line corresponds to the gastroesophageal junction. In patients with Barrett’s esophagus, the columnar epithelium extends proximally up the esophagus." The Z-line can also be irregular if a hiatial hernia is present.

www.gastro.com/endoscopic-images.html

The esophagus meets with the stomach which is the salmon color and that also is normal. You can see that where they meet it is somewhat irregular, and it is called the Z-line. The Z-line, as you can tell from its name, is quite irregular and that is entirely normal.

www.giejournal.org/article/S0016-5107(00)14220-8/abstract

Background: Subtle irregularity and short tongues of columnar appearing mucosa (CAM) at the Z-line are frequently observed during EGD. Although the risk of short segments of Barrett's esophagus progressing to esophageal adenocarcinoma is not yet clear, some experts have advocated placing all patients with any length of Barrett's esophagus into an endoscopic surveillance program.

www.hopkinsmedicine.org/.../barretts_esophagus.pdf

A, Normal esophageal epithelium; B-D, variants of Barrett’s esophagus. The squamocolumnar junction is therefore displaced into the esophagus and no longer marks the esophagogastric junction. Barrett's mucosa may extend upward in a continuous pattern in which the entire circumference of the distal esophagus is covered by columnar mucosa.