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A lacerated or ruptured spleen, an enlarged spleen and spleen cancer are some causes of spleen-related pain, according to LiveScience. The spleen is located in the upper left quadrant of the abdomen, so pain in that area... More »

When a person has an enlarged, painful spleen, diagnosing and treating the underlying causes can prevent the need for surgery in most cases, according to WebMD.com. Limiting activities that can rupture a spleen is very i... More »

An enlarged spleen can cause a feeling of pain or fullness in the left upper abdomen, according to Mayo Clinic. The pain sometimes spreads to the left shoulder. Other symptoms of an enlarged spleen include anemia, fatigu... More »

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