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The general structure of the endoplasmic reticulum is a network of membranes called cisternae.These sac-like structures are held together by the cytoskeleton.The phospholipid membrane encloses the cisternal space (or lumen), which is continuous with the perinuclear space but separate from the cytosol.The functions of the endoplasmic reticulum can be summarized as the synthesis and export of ...


The lumen of the endoplasmic reticulum (ER) is the area enclosed by the endoplasmic reticulum membrane, an extensive network of membrane tubules, vesicles and flattened cisternae (sac-like structures) found throughout the eukaryotic cell, especially those responsible for the production of hormones and other secretory products.


The Endoplasmic Reticulum. The endoplasmic reticulum (ER) is a network of flattened sacs and branching tubules that extends throughout the cytoplasm in plant and animal cells.These sacs and tubules are all interconnected by a single continuous membrane so that the organelle has only one large, highly convoluted and complexly arranged lumen (internal space).


The ER membrane separates the ER lumen from the cytosol, and it mediates the selective transfer of molecules between these two compartments. Figure 12-35Fluorescent micrographs of the endoplasmic reticulum(A) Part of the ER network in a cultured mammalian cell, stained with an antibody that binds to a protein retained in the ER.


The endoplasmic reticulum (ER) is a continuous membrane system that forms a series of flattened sacs within the cytoplasm of eukaryotic cells.; All eukaryotic cells contain an ER. In animal cells, the ER usually constitutes more than half of the membranous content of the cell.


Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi.


Proteins that are supposed to stay in the ER lumen (the interior space within the ER) are marked by having an amino acid sequence called a KDEL sequence at their C-termini. This is a sign to the cell that these proteins are intended to stay in the ER, not get transported to other places.


The entire endoplasmic reticulum is enclosed by a continuous membrane and is the largest organelle of most eukaryotic cells. Its membrane may account for about half of all cell membranes, and the space enclosed by the ER (the lumen, or cisternal space) may represent about 10% of the total cell volume.


5. SRP is released and recycles into the cytosol to bring a new ER signal sequence 6. Nascent protein is transported into the lumen of the RER through the translocon as it is being synthesized 7. the protein is translocated across the RER membrane via the translocon or pore


Proteins are produced for the plasma membrane, Golgi apparatus, secretory vesicles, plant vacuoles, lysosomes, endosomes and the endoplasmic reticulum itself. Some of the proteins are delivered into the lumen or space inside the ER whilst others are processed within the ER membrane itself.