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chemistry.elmhurst.edu/vchembook/571lockkey.html

This means that enzymes specifically react with only one or a very few similar compounds. Lock and Key Theory: The specific action of an enzyme with a single substrate can be explained using a Lock and Key analogy first postulated in 1894 by Emil Fischer. In this analogy, the lock is the enzyme and the key is the substrate.

www.udemy.com/blog/lock-and-key-hypothesis

Lock and Key Hypothesis. In order to explain why enzymes have such a high level of specificity, Emil Fischer in 1894 suggested that both a substrate and an enzyme have specific geometric shapes that fit exactly into each other. This idea of both substrates and enzymes having a natural geometric fit has been called the lock and key hypothesis.

www.reference.com/science/lock-key-model-enzymes-6ddf51d4ab150a27

The lock-and-key model refers to the way in which a substrate binds to an enzyme's active site. Similar to how a key has to be the correct one for a lock, no reaction takes place if an incorrect substrate tries to bind.

www.bbc.co.uk/bitesize/guides/zwxv6yc

Enzymes are biological catalysts which speed up reactions. They are specific for their substrate. The lock and key hypothesis models this. Enzymes are denatured at extremes of temperature and pH.

astarbiology.com/edexcel/lock-key-theory

LOCK & KEY THEORY Enzymes (e.g. globular proteins) are biological catalysts which speed up chemical reactions without being use dup in the process. They are vital b/c otherwise reactions would be too slow and the body can’t meet demands => cells die. Each enzyme only catalyses one reaction/c only a specific shaped […]

en.wikipedia.org/wiki/Lock_and_key_model

"Lock and key" model. To explain the observed specificity of enzymes, in 1894 Emil Fischer proposed that both the enzyme and the substrate possess specific complementary geometric shapes that fit exactly into one another. This is often referred to as "the lock and key" model.

www.youtube.com/watch?v=NGRzJWaJk7w

Mechanism of Enzyme Action - Lock And Key Model And Induced Fit Model | Biology Class 11 By Khalid - Duration: 8:08. Anjum Academy 5,229 views. 8:08.

www.youtube.com/watch?v=hXeMb-CBTW0

Mechanism of Enzyme Action - Lock And Key Model And Induced Fit Model | Biology Class 11 By Khalid - Duration: 8:08. Anjum Academy 5,093 views. 8:08.

www.ncbi.nlm.nih.gov/pmc/articles/PMC2801061

Therefore, the mutations cause the enzyme to switch from an induced fit to a lock and key mechanism, increasing its catalytic efficiency. This effect is important to render the mutant enzyme usable for in vivo incorporation of non-canonical amino acids into proteins.

education.seattlepi.com/explain-lock-key-model-enzyme-reactions-6351.html

Each enzyme has receptor sites that allow specific substrates to enter and create a chemical reaction product. The enzyme sites work like the keyhole in a lock. Like the lock on a door, only certain keys will fit in the keyholes, and perhaps only one key will open the lock.