Benzoylecgonine is the compound tested for in most substantive cocaine urinalyses. It is the corresponding carboxylic acid of cocaine, its methyl ester. It is formed in the liver by the metabolism of cocaine, catalysed by carboxylesterases , and subsequently excreted in the urine .
Amitava Dasgupta, in Alcohol, Drugs, Genes and the Clinical Laboratory, 2017. Analysis of cocaine as benzoylecgonine. Cocaine abuse is usually confirmed by detecting the presence of benzoylecgonine, an inactive metabolite of cocaine in the urine.
Benzoylecgonine, also known as ecgonine benzoate, is the main metabolite of cocaine. Produced by hydrolysis, benzoylecgonine can be detected in urine for a minimum of 5 days after usage of cocaine.
Most drug tests that check for cocaine look for benzoylecgonine, a product of the body's metabolism of the drug. Other illegal drugs, including opium and psilocybin, do not produce this byproduct and so can't cause a false positive for cocaine.
Benzoylecgonine is the major metabolite of cocaine.It is formed by hydrolysis of cocaine in the liver, catalysed by carboxylesterases. It is excreted in the urine of cocaine users after processing in the liver. It is the main pharmaceutical ingredient in the investigational drug Esterom, a topical solution used for the relief of muscle pain that is not FDA approved or on the market in the ...
Positive drug-testing results for cocaine (as benzoylecgonine, the major metabolite) may be encountered in subjects who have undergone such procedures. A patient may be positive up to 72 hours after an otolaryngologic procedure where cocaine is used as an anesthetic.
If benzoylecgonine, the main metabolite of cocaine is detected, the subject cannot claim that the result is a false positive due to Novocaine administration, or any other "-caine" drug.
Cocaine is eliminated from your blood within 4 – 6 hours, whereas benzoylecgonine can be present for up to 6 days after administration. Benzoylecgonine is detectable in your blood within 30 minutes of cocaine consumption.
The metabolite of cocaine, benzoylecgonine, is screened by most of the testing labs. This shows in urine till 3 to 5 days, or even a month if the dose intake was heavy. It’s a fingerprint metabolite of cocaine. No other drug or prescription medicine produces exactly the same metabolite as benzoylecgonine.
Cocaine is a highly abused drug that is most frequently detected in the urine as the metabolite benzoylecgonine and usually as part of a multiclass drug profile. In preëmployment drug testing, the presence of cocaine (benzoylecgonine) should be confirmed by MS.