Benzoylecgonine is the compound tested for in most substantive cocaine urinalyses. It is the corresponding carboxylic acid of cocaine, its methyl ester. It is formed in the liver by the metabolism of cocaine, catalysed by carboxylesterases , and subsequently excreted in the urine .
Cocaine abuse is usually confirmed by detecting the presence of benzoylecgonine, an inactive metabolite of cocaine, in the urine. In general, the antibodies used in cocaine immunoassays are specific for benzoylecgonine , and these assays, unlike amphetamine immunoassays, demonstrate good specificity as well as sensitivity.
Benzoylecgonine is the main metabolite of cocaine. It is also its signature metabolite. The presence of this metabolite is almost a certain indication that a person has consumed the drug. Therefore, in cocaine users, benzoylecgonine testing in urine is commoner than testing of cocaine itself. Benzoylecgonine may be visible in your system longer ...
The presence of benzoylecgonine >LOQ indicates exposure to cocaine within 5 days prior to specimen collection. Metabolites. Cocaine is metabolized to several inactive metabolites, the predominant one being benzoylecgonine. Cocaine → Benzoylecgonine. Confirmation Tests: Cocaine Confirmation, Urine; Approximate Detection Times
Cocaine is a highly abused drug that is most frequently detected in the urine as the metabolite benzoylecgonine and usually as part of a multiclass drug profile. In preëmployment drug testing, the presence of cocaine (benzoylecgonine) should be confirmed by MS.
Benzoylecgonine, also known as ecgonine benzoate, is the main metabolite of cocaine. Produced by hydrolysis, benzoylecgonine can be detected in urine for a minimum of 5 days after usage of cocaine.
Cocaine is metabolised to a variety of compounds, the major metabolites being Benzoylecgonine (BZG), Ecgonine, and Ecgonine Methyl Ester. BZG is produced upon loss of the methyl group and is the major urinary metabolite. The half-life for cocaine is short, approx 0.8 ± 0.2 hours, while the half-life of BZG is 6 hours.
Cocaine metabolite (benzoylecgonine) in hair and urine of drug users. Martinez F(1), Poet TS, Pillai R, Erickson J, Estrada AL, Watson RR. Author information: (1)Department of Family and Community Medicine, University of Arizona, Arizona Health Sciences Center, Tucson 85724.
Cocaine is metabolized in the liver where it is quickly turned into the by-product of benzoylecgonine, the most common metabolite tested for. Depending on how much is in the blood and able to travel throughout your body, how fast your metabolism is, and your body mass index, or fat percentage, the benzoylecgonine will break down into the other ...
Cocaine metabolite can also be detected in the urine specimen of the physician who is performing the procedure. 4 Jacobson, et al, studied the effect of use of ophthalmic solution containing cocaine on urine excretion of benzoylecgonine in patients.