In general, the safest seats on a Boeing 737 are the ones towards the back of the plane. Analysis of airplane crashes that occurred between 1971 and 2007 and had both fatalities and survivors showed that the majority of crash survivors were sitting in the back third of the plane.
The front portion of an aircraft, encompassing business and first class, is generally the least safe place to sit, with a survival rate of 49 percent. The middle of the plane, in front of and over the wings, has a survival rate of 56 percent. The rear cabin, starting behind the wings and continuing to the back row of the plane, has a survival rate of 69 percent.