The typical fuel mileage of a 2015 Ford F-350 pickup truck with a diesel engine is approximately 14.7 miles per gallon. Reported fuel efficiency varies between model years, with newer trucks usually achieving better fuel mileage than older vehicles.
In addition, differences in the configuration of a given truck may affect its fuel mileage as compared to trucks of the same model. Ford F-350s with four-wheel drive or extended cabs is likely to be less efficient than F-350s without those features due to the additional weight of extra cab space and four-wheel drive systems. Fuel efficiency of F-350s appears to improve each year. For example, the 1999 model averages just 12.6 miles per gallon.