To replace an Intel motherboard, back up important files and registration keys, deactivate or uninstall activated applications, and update drivers. Place the computer in a flat, dry and static-free environment. Constantly ground yourself with a static strap during the entire process. Disconnect all wiring and cables, pull out mounting screws, and carefully wiggle out the motherboard. Install the back plate, motherboard, CPU, memory and cooler. Attach the connectors and review that all components are installed properly before booting up.
Back up all important files to an external hard drive and create an image backup of the entire hard drive as an optional step. Obtain written records of program activation keys prior to replacing the motherboard. Since some activated programs might see replacing the motherboard as an attempt to copy software illegally, temporarily remove or deactivate all activated programs. Update drivers to the most recent versions, especially when upgrading to a newer motherboard.
To remove the motherboard, carefully disconnect connectors and remove the CPU cooler, old memory and CPU. Store all removed hardware in static-free containers. Disconnect wiring and cables and pull out the ATX I/O plate and mounting screws using a number two Phillips screwdriver. Carefully wiggle out the motherboard.
Make sure the standoffs that accept mounting screws are properly installed. Install the ATX I/O back plate. Carefully insert the new motherboard, memory, CPU and cooler in place. Follow the motherboard's manual and attach the connectors. Check that connections and hardware are properly installed, attach external cabling, such as the power cable and mouse, and boot up the system.