A computer mouse may freeze or become unresponsive because of accumulated dirt, use of the wrong settings or a bad surface. An incompatible driver, a loose cable or interference from other input devices may also cause the computer mouse to function abnormally.
When troubleshooting an unresponsive mouse, try plugging it in a different port or even another computer to see if it works. If the mouse is optical, there must be no obstructions blocking its laser sensor. For a mechanical mouse, check that no dirt is stuck in its ball and rubber-coated wheels. Also check to see if the mouse cable is damaged. Sometimes the cable's plastic insulation layer may look fine, but the wires inside are damaged or even severed. Also check online to see if there is a driver update for the mouse. For a wireless mice, try changing the batteries.