To change your homepage to MSN Latino, go to the MSN Latino website and sign in with a Microsoft account via the icon in the upper right-hand corner, as of 2015. If necessary, create a Microsoft account before proceeding.
After signing in to your Microsoft account, look at the second subheading at the top of the page, which starts with a WINDOWS 10 link. In the third space from the left, there are instructions under the heading of "Haz MSN tu pagina de inicio," which translates in English to "Make MSN my home page." Click this link, and your home page automatically switches to MSN Latino.