Henry "Lou" Gehrig was born on June 19, 1903, and spent his childhood in New York City before attending Columbia University in 1921. Scouted for his skills in baseball, Lou Gehrig played his first game as a member of the New York Yankees on June 15, 1923. During his illustrious career, Gehrig received a diagnosis of amytrophic lateral sclerosis. Lou Gehrig subsequently retired from baseball and succumbed to the disease on June 2, 1941.
Lou Gehrig's career with the New York Yankees included his first World Series win on Oct. 5, 1927. Nicknamed "The Iron Horse," Lou Gehrig broke major league records and set a precedent for new statistics in the sport, becoming the first player to hit four home runs in one game on June 3, 1932.
Following the onset of unknown health issues, Lou Gehrig removed himself from the Yankees' line-up on May 2, 1939, after 2,130 consecutive games. Doctors admitted him to Mayo Clinic in Rochester, Minnesota, on June 13, 1939, for testing, and he received his diagnosis of ALS on June 19, 1939.
The New York Yankees announced Lou Gehrig's official retirement from baseball on June 21, 1939 and celebrated Lou Gehrig Appreciation Day at Yankee Stadium on July 4th, where he delivered his famous "Luckiest Man in the World" speech. He was then inducted into the Baseball Hall of Fame on December 7th.