The quarterback that has thrown the most career interceptions in NFL history is Brett Favre. During a 19-year career in the NFL, he threw a total of 336 interceptions.
The quarterback who has thrown the most interceptions in one season is George Blanda, who threw a total of 42 interceptions during the 1962 season; he stands right behind Favre with the second-highest total of career interceptions at 277. The quarterback who threw the most interceptions during the 2014-2015 season is Chicago Bears quarterback Jay Cutler. As of the end of the 2014-2015 NFL season, among active quarterbacks, Peyton Manning has thrown the most career-long interceptions with a total of 234.