As of 2014, Reggie Wayne is married, and he has children, as well. However, he and his wife value privacy in their personal life, and few, if any, pictures of the couple exist for public viewing.
Wayne and his wife were married in 2009. However, a few months later, an alleged affair on his part became public. Wayne's wife allegedly discovered roughly $95,000 worth of credit card transactions made by a woman named Natasha McKenzie, who was described as both Wayne's ex-girlfriend and mistress. After his wife discovered the charges, Wayne filed an official police complaint against McKenzie. Wayne later denied any relationship with McKenzie.