As of January 2015, Brett Favre has the most wins while playing quarterback in the National Football League, with 186. However, Favre retired at the end of the 2010 season, after a concussion injury side-lined him. Active quarterbacks Peyton Manning and Tom Brady are close behind with 179 and 160 wins respectively.
During his 20-year career playing for the Atlanta Falcons, Green Bay Packers, New York Jets and Minnesota Vikings, Brett Favre amassed a win-loss record of 186 wins and 112 losses. Of those, 160 victories occurred during his time with the Packers. Payton Manning has a record of 179-77 during his 17-year career with the Indianapolis Colts and Denver Broncos. Tom Brady has spent his 15-year career with the New England Patriots, and has a win-loss record of 160-47.