The record for most combined runs in a single Major League Baseball game is 49 runs, achieved in a contest between the Chicago Cubs and Philadelphia Phillies on Aug. 25, 1922. The Cubs won the game 26-23.
In that 1922 contest, the teams combined for 51 hits. The Cubs scored most of their runs in just two innings: 10 runs in the second and 14 in the fourth. The Cubs also hold the record for most runs by a single team in a game, as it scored 36 runs against the Louisville Colonels on June 29, 1897. The team was then known as the Chicago Colts.