While both Andre the Giant and the Big Show grew to enormous size due to the same condition, acromegaly, the two men are not related. Andre the Giant was born in France, while the Big Show grew up in South Carolina.
Andre the Giant's real name was Andre Rene Roussimoff, and he had one daughter named Robin, who was born in 1979. The Big Show's real name is Paul Wight, Jr., and he is named after his father, who was not a wrestler. When Wight was young, he suffered from the same acromegaly disorder that caused Andre's growth, but he had a tumor removed that halted the progression of the disease.