The nuclear lamina is a structure in the nucleus of eukaryotic cells located near the inner nuclear membrane and the peripheral chromatin. It plays a role in various nuclear activities including DNA replication, nuclear and chromatin replication, RNA transcription, regulating the cell cycle and apoptosis.
The nuclear lamina is composed of lamins and lamin-associated proteins. The lamins interact with these proteins as well as the chromatin-associated proteins. The nuclear lamina is an essential component of metazoan cells. Mutations in genes in the nuclear lamina can cause several heritable human diseases. These diseases include limb girdle muscular dystrophy, familial partial lipodystrophy, axonal neuropathy and dilated cardiomyopathy with conduction system disease.