The number of chromatids present during the prophase state of mitosis is double the number of chromosomes. The specific number depends on the number of chromosomes in the cell. Human beings, for example, have 46 chromosomes; during prophase, each human cell has 92 chromatids.
During the final stages of interphase, prior to prophase, each chromosome duplicates itself, resulting in two identical chromatids for each chromosome. During prophase, the chromosomes coil and the nuclear membrane disappears. Microtubules called spindle fibers form in preparation for cell division. Following prophase, during metaphase, anaphase and telephase, the chromatids are separated and the cell divides, resulting in two identical cells.