What Is LOD Score?

lod-score Credit: David J Laporte/Flickr/CC-BY-2.0

In genetics, LOD, short for "logarithm of the odds," is a score that helps to determine whether certain traits are likely to be inherited. The closer two genes are to each other on the chromosome, the more likely a person is to inherit those genes together.

An LOD score can be used to determine whether a person will inherit a genetic disease. For example, if a gene and a disease gene have an LOD score of 3, that person has a 1,000 to one chance of inheriting that trait. A higher score indicates a higher probability of inheriting a specified trait.