How Do You Find the Kozak Sequence?


Quick Answer

The Kozak sequence is identified by its specific molecular components, notated as (gcc)gccRccAUGG. The sequence is used in biology and bioinformatics. It occurs on messenger RNA, which is a group of molecules of ribonucleic acid that sends genetic information from DNA to complex molecules that make protein.

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The Kozak sequence was first described by Marilyn Kozak, a professor of biochemistry at the Rutgers University as of 2014. Kozak studies the mechanisms that generate proteins and has published more than 70 scientific articles on the subject.

The process by which cells make proteins is known in genetics and molecular biology as translation. It occurs when a ribosome, a group of molecules that synthesize protein, decodes messenger RNA. The decoded genetic information makes polypeptides, which are chains of amino acids. The ribosome decodes the information by binding specific genetic components, resulting in gene expression.

All life is based on the gene expression process. When evolutionary change occurs, it is during this process through changes to location, timing and amount of genetic information expressed.

Many antibiotics work by slowing the translation process. The drugs that work in this manner include tetracycline and anisomycin. By using the translation process mechanism, these antibiotics target bacterial infections without hurting other cells.

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