Hemophilia is a bleeding disorder caused by a X-linked recessive inheritance, states the National Institute of Health. This disorder is passed down from female carriers who have a mutated gene on an X-chromosome. There are different forms of this disorder, which include hemophilia A, B and C, according to the Mayo Clinic.
People with this condition, which generally affects more males than females, lack certain blood clotting proteins that can lead to blood loss. Patients with hemophilia A have a mutation in the F8 gene, and the mutation occurs in the F9 gene in patients with hemophilia B, relates the National Institute of Health. These two genes are associated with proteins that are coagulation factors VIII and IX, respectively.
Although hemophilia A and B generally affect males and is passed down through the maternal line, hemophilia C can affect both boys and girls and both parents can pass this defective chromosome, reports the Mayo Clinic. Hemophilia C is associated with the clotting factor XI and is a milder form of this disorder.