The seven member crew of the space shuttle Columbia were killed when the shuttle broke up during re-entry in February 2003. Remains for all seven were found among the wreckage of the shuttle.
It is believed that the Columbia crew had only 40 seconds between losing control of the space shuttle and the depressurization that ultimately led to their deaths. According to NASA's investigation, the crew could not have regained consciousness after the depressurization. The break up of the shuttle was considered to have been not survivable, with the astronauts' own suits and seats failing to protect them during the shuttle's break up.