What is genotyping by sequencing?


Quick Answer

Genotype by sequencing is a type of genetic recombination that utilizes next generation sequencing techniques to construct reduced representation libraries for the Ilumina platform. The genotype by sequencing system is frequently referred to as GBS and offers many benefits that increase the efficiency of genetic analysis.

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Full Answer

According to the Institute for Genomic Diversity at Cornell University, the GBS system is a simple but strictly ordered method of reducing genome repetitiveness and complexity. One of the ways it achieves this is by generating single nucleotide polymorphisms, or SNPs, in large numbers. Other important benefits of the GBS system are inexpensive bar coding, a decreased number of purification steps, reduced sample handling and no size fractionation.

Next generation sequencing technologies are becoming increasingly important to genotyping by sequencing. GBS is a cost effective tool for studying genome-assisted breeding in plants and animals. Genotyping by sequencing research has been successfully conducted on a variety of organisms, including cassava, willow, rice, maize, apples and sorghum.

New technologies are being introduced in which chemically encoded information is translated into digital information on a semiconductor chip. Life Technologies sells products that utilize these new technologies, and its website shares articles and news items about emerging techniques for genetic analysis.

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