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What is DNA gyrase?

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DNA gyrase is a bacterial enzyme that catalyzes the ATP-dependent negative supercoiling of double-stranded, closed-circular DNA, according to the Critical Review of Biochemical and Molecular Biology. Also referred to as topoisomerases, gyrase is a member of a category of enzymes that control the topological transitions of DNA.

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The Critical Review of Biochemical and Molecular Biology states that DNA gyrase relieves strain while helicase unwinds double-strand DNA. This process yields the negative supercoiling of the DNA. According to the journal, antibiotics like novobiocin, nalidixic acidand ciprofloxacin target bacterial DNA gyrase when a person is suffering from a disease or an infection.

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