One main difference between protists and bacteria is that protists are eukaryotic organisms, while bacteria are prokaryotes. Another difference is that protists belong to the kingdom Protista, while bacteria are members of the Monera kingdom. Bacteria are uni-cellular organisms that do not contain organelles like a nucleus or chloroplasts.
Protists are also single-celled organism, but they do have a nucleus and other intracellular organelles. Examples of protists are amoeba and paramecium.
Some similarities between these two organisms are that they both can be uni-cellular organisms, which can either stay in one position or move through structures like flagella. Another similarity is that members of each kingdom can either be autotrophs or heterotrophs. Autotrophs can make their food, while heterotrophs cannot do this.