Where in the Body Is Creatine Kinase Made?

The production of the isoenzyme creatine kinase occurs in the skeletal muscles, heart and brain of the human body. Production of enzyme creatine, the base component of creatine kinase, occurs in the liver.

The human body produces three main types of creatine kinase, specifically CK-MM in the skeletal muscles, CK-MB in the heart and CK-BB in the brain. The body uses creatine kinase to help produce adenosine triphosphate and adenosine phosphocreatine, two high-energy molecules utilized by muscles to contract muscle fibers. High levels of creatine kinase in the blood can indicate the presence of muscular degeneration or another neuromuscular disease. Other potential conditions indicated by elevated levels of creatine kinase include heart attacks, acute kidney failure, rhabdomyolosis, recent exercise or hypothermia. Also those who take statins and other forms of cholesterol medication sometimes require monitoring of their creatine kinase levels due to the elevated risk of rhabdomyolosis.

The liver produces creatine, the main component of creatine kinase, from arginine and glycine. The human body typically requires about 2 grams of creatine daily to satisfy its energy needs. Despite this, the average human diet provides only 1 gram of creatine daily. To overcome this deficiency, scientific research conducted by Avicena indicates that ingestion of creation supplements can satisfy the body's daily needs and potentially boost the body's overall energy levels.