At age six to seven weeks, a veterinarian administers a combined vaccine for coronavirus, distemper, parainfluenza, parvovirus, and hepatitis, repeating it at nine weeks, 12 weeks and 16 weeks of age, according to petMD. He may also vaccinate against lyme disease with the third combined vaccine at age 12 weeks.
In this case, the puppy needs a second lyme vaccination two weeks later. The lyme vaccine is an annual one after the second shot, states petMD. When the puppy is 12 to 16 weeks old, he also needs a rabies vaccine. Since humans can contract rabies, state or local laws dictate when a vet gives this vaccine. Some veterinarians advise vaccinating certain breeds at least twice for parvo, with the last shot falling at the 20-week mark.