The prairie dog has become endangered mostly due to loss of habitat from urban and agricultural development. There are several species of prairie dogs, each facing endangerment from different causes, including plague.
The black tail prairie dog is nearly extinct, as of 2014. It has been driven to this state primarily due to having no immunity to plague. Gunnison's prairie dog has been threatened by plague, land development and gas and oil drilling. Loss of habitat to agriculture has endangered the Mexican prairie dog. The Utah prairie dog has become threatened from livestock grazing, plague and habitat loss. As of 2010, the U.S. Fish & Wildlife Service denied the white-tailed prairie dog protections under the Endangered Species Act.