Yohimbine can cause hypotension and an increase in heart rate, advises Drugs.com. It also has the potential to cause an allergic reaction, confusion, anxiety and tremors.
Yohimbine is a chemical derived from the yohimbe tree, informs WebMD. The chemical is found in the bark of the tree, which is processed to produce yohimbine.
In animals, yohimbine is labeled for use in the reversal of sedation from alpha-2 agonists, such as xylazine or dexmedetomidine, states InChem.org. It is used to treat dogs, cats, horses, steer and deer. Due to the fact that it has the potential to cause hypotension and tachycardia, atipamezole is a better option, advises the Veterinary Anesthesia & Analgesia Support Group.
Overdoses of yohimbine cause similar effects as clinical doses, reports InChem.org. Increases in heart rate and hypotension are the most common signs. In humans, central nervous system depression leading to coma, respiratory depression, vomiting, diarrhea, and flushed skin have been noted. Humans who have inhaled yohimbe bark have experienced hallucinations. No deaths have been reported in human overdoses.
In addition to the veterinary formulation of yohimbine, yohimbe bark is available in supplements or brewed into tea, states WebMD. While testing has been done on drugs containing the chemical extract, yohimbine, there are no studies to suggest whether or not the supplements have the same effect as their processed counterpart.