According to Vetstreet, Great Danes shed moderately. While Great Danes have short hair, they tend to shed like other short-haired dog breeds. Great Danes tend to shed more in the spring and fall. However, proper grooming can minimize shedding.
The best way to minimize shedding in Great Danes is through weekly brushing with a soft bristle brush or rubber brush mitt. During heavy shedding months, it may help to brush Great Danes on a daily basis. While bathing can help remove excess fur, Great Danes have sensitive skin and should only be bathed when they are dirty or smell bad.