There are dozens of Great Dane rescue organizations in the United States. All-about-great-danes.com lists the nation's Great Dane rescues by state. Most states have at least one Great Dane rescue.
Most Great Dane rescues now list adoptable Danes on Petfinder.com. Petfinder.com offers searches by breed, age and size of dog. Many Great Dane rescues, such as Great Dane Rescue of New England, are willing to work with an adoptive family to transport dogs from other states to their forever home. The adoption process for surrendered Great Danes is often rigorous and may include an application, home visit, and application or adoption fee to ensure a good pet and owner match and offset the cost of fostering the Great Dane.