Unaffected by the blowfish's poisonous toxins, tiger sharks and sea snakes are most known for eating these fish. Predators not scared away at the sight of the long, sharp spikes exposed in defense almost always meet a nasty demise.
Various predators are drawn to the slow, clumsy swimming style of the blowfish. As predators approach, the species inflates, exposing the toxic spikes. Nearly all 120 species contain tetrodotoxin, instantly lethal to most sea creatures, with one blowfish fish bearing enough poison to kill 30 human beings. The blowfish is the second most poisonous creature in the world. The golden poison frog is the most lethal.