Bufferin is safe for dogs in moderation, according to Vetinfo. Bufferin is a brand name for buffered aspirin, or aspirin that is coated with a compound that neutralizes the acid contained within the aspirin tablet.
Buffered aspirin is a medication in the class of non-steroidal anti-inflammatory drugs. It is used to reduce pain and inflammation. According to Vetinfo, it is safe to dose dogs at 5 milligrams to 10 milligrams per pound of body weight. This dosage is administered every 8 to 12 hours as needed.
According to the U.S. National Library of Medicine, it is not safe to give Bufferin to puppies under 6 months of age. Dogs that are given doses higher than 10 mg per pound of body weight in an eight-hour period should be taken to the veterinarian for medical attention.