Can I Give My Puppy Benadryl?

As PetMD points out, Benadryl, which is the brand name for the over-the-counter antihistamine diphenhydramine, is used to treat symptoms associated with an overproduction of histamine. The body produces histamine in response to allergies; associated symptoms include itching, inflammation and difficulty breathing. Benadryl is also used to treat motion sickness and hyperexcitability in dogs. Only give Benadryl to dogs and puppies when advised to do so by a veterinarian.