A calico Persian is a Persian cat with a coat of three colors, such as red, black and white or chocolate, red and white. Because of the genetics involved, calico cats are almost always female and though male cats are born rarely, they are usually unable to reproduce.
The piebald, or spotted, pattern is a common genetic mutation in domestic animals. Calico coloring has always been present in the Persian breed. However, among people involved in cat shows, the pattern was not popular or fashionable for a long time, and those cats were not purposely bred. In some cases, calico Persians were even euthanized to remove them from the gene pool. Calico Persians first became popular in the United States, and the interest eventually spread to England.